57/M with ALTERED SENSORIUM SECONDARY TO HYPOGLYCEMIA





 Cheif complaints and HOPI 


A 56 year old male patient who is a resident of koilagudem (nalgonda district)who is a daily wage labourer by occupation brought to the casualty  in unresponsive state at 1:30 Am .patient was found drowsy from 1 pm on 25/04/2023 And suddenly developed seizure like activity associated with slurring of speech,uprolling of eyeballs,stiffness of all four limbs,

Associated with involuntary defecation and micturition and found unresponsive. 

No h/o fever ,cough.

No h/o neck stiffness and projectile vomitings. 

No h/o generalised weakness ,tingling,numbness.

No h/o head trauma.

 Patient was apparently asymptomatic 6 months back then he developed multipleSwellings Over the Cheek, Forearm, legs with dischargingPus with no pain. for which he went to an RMP and he prescribed Antibiotics but it resolves on for some days and then reappears in 10-15days. He also developed swelling on the nose 6 months back the RMP Removed the pus ,After somedays it healed but the nose became a saddle nose.

1 month back He developed Edema of legs which was insidious in onset and gradually progressive in nature which is progressed from ankle to knees which is of pitting type. for which they went to hospital and was diagnosed with DM2 and .on glimiperide 1mg and metfromin 500mg.


PAST HISTORY:

No history of similar complaints in the past. 

Known case of Diabetes  type 2 since 1 month.on glimiperide 1mg and metfromin 500mg.

known case of asthma since 30 years. 

Not a known case of Diabetes,HTN,Epilepsy,CAD,TB.

DAILY ROUTINE:Patient is a daily wage labourer by occupation he stopped his occupation 6to7 years ago because he vision becoming cloudy and he is getting old

DAILY ROUTINE OF THE PATIENT BEFORE DIABETES

He daily wakes at 5AM and he does his daily activities and fresh up ,takes bath and drinks decoction 7am and then at 10 am he take his breakfast which contains rice with curry and after taking his breakfast he chit chat with neighbors and lie down for sometime and then In the afternoon at 1pm or 2pm he takes his lunch which consists of rice as well as some vegetable curry and after that  he sleeps for some time watch TV and drinks decoction at 5pm and at 8pm he takes his dinner which consists of rice and a vegetable curry and night he sleeps at 10 pm .he has the habit of drinking decoction  in the night like tow times at 12or1am and at3 or 4 am.

 DAILY ROUTINE OF THE PATIENT AFTER BEING DIAGNOSED WITH DIABETES .

PATIENT REDUCED TAKING DECOCTION TOO FREQUENTLY AND STARTED TAKING ONLY IN THE MORNING AT 7AM AND HIS MEALS(RICE WITH CURRY) WERE REPLACED BY GADAKA(PORRIDGE)AND JONNA ROTTE (JOWAR ROTI).3 TIMES A DAY.


FAMILY HISTORY:

No similar complaints in the family.

PERSONAL HISTORY: 

DIET : MIXED 

APPETITE: ADEQUATE 

SLEEP:NORMAL 

BOWEL AND BLADDER :REGULAR 

ADDICTIONS: NO ADDICTIONS. 


TREATMENT HISTORY:

DELPHILIN AND DACADRAN SINCE 30 YEARS (SOS)

GENERAL EXAMINATION:

Patient is unresponsive. 

Pupils dilated sluggishly reactive.

Poorly built and poorly nourished. 

Vitals: Pulse rate during admission 52 bpm on atropine 98bpm.

Respiratory rate:32cpm.

Spo2 :98%@RA.

Bp:120/90MMHG 

Temp:afebrile. 


SYSTEMIC EXAMINATION:

CVS:S1,S2 HEARD,NO MURMURS. 

RS:BAE+,NVBS.

P/A: SOFT ,NON TENDER. 


CNS: Patient is unresponsive at first. 


HMF:INTACT

MOTOR EXAMINATION 

  TONE: rt       lt

      UL: N.      N

      LL:N        N

REFLEXES:

      B:2+       2+

      T:2+        2+

      S:2+        2+

      K:2+        2+

      A2+         2+

      P:2+        2+


INVESTIGATIONS AND CLINICAL IMAGES:

26/04/23













27/04/23












28/04/2023






29/04/2023







                           30/04/23
                











 
















                        26/04/2023




27/04/23



Usg


ECG:

HACHETS FACIES:
Frontal balding .
Atrophy of temporalis muscle.







PROVISIONAL DIAGNOSIS:

ALTERED SENSORIUM SECONDARY TO ?HYPOGLYCEMIA.

Treatment:

1IVF NS @@ 50ml/hr.

2.Inj:25%DEXTROSE INFUSION @10ml/hr 

Increase/decrease according to GRBS.

3.INJ:PIPTAZ 4.5 g/Iv/TID

4.Inj.CLINDAMYCIN TID

5.TAB.DOLO 650 mg/po/(sos)

................FOLLOW UP....................



27/04/2023

S:

No fever spikes

Stools passed (4episodes of loose stools)

His swellings on the forearm was not subsided and pus is sent for c/s


O:

Patient is conscious,coherent,cooperative

Temp:99.6°F

BP:100/70mmhg.

PR:80bpm.

RR:20cpm.

CVS:S1,S2HEARD ,NO MURMURS. 

RS:BAE+,NVBS.

GRBS:437mg/dl.


A:ALTERED SENSORIUM RESOLVED.

RECURRENT HYPOGLYCEMIA 2°TO ? LEFT UPPER LOBE ABSCESS.

WITH ANEMIA(NORMOCHROMIC NORMOCYTIC). 

WITH HYPOKALEMIA 2°TO GI LOSSES, WITH DM2 SINCE 1 MONTH


P:

IVF-NS@75ml/hr.

INJ:25% DEXTROSE INFUSION @45ml/hr.

INJ:PIPTAZ 4.5 g /iv/TID.

INJ:CLINDAMYCIN 600mg/iv/TID.

Tab.DOLO 650mg/po/sos.

Tab.SPOROLAC PO/TID


QUESTIONS IN THE ROUNDS....

1.GOLD STANDARD TEST FOR WEGENERS 

https://pubmed.ncbi.nlm.nih.gov/14968341/


2.WHY IS HYPOGLYCEMIA IN THIS PATIENT??


3.DANGER AREA OF FACE??



4.WHY DOES SEPSIS CAUSE HYPOGLYCEMIA???


5.HOW IS CBNAAT DONE??

https://youtu.be/yjTNB7g41so


28/04/2023


S:

No fever spikes

Stools passed (2episodes of stools)

O:

Patient is conscious,coherent,cooperative

Temp:Afebrile 

BP:110/60mmhg.

PR:76bpm.

RR:19cpm.

CVS:S1,S2HEARD ,NO MURMURS. 

RS:BAE+,NVBS.

P/A:SOFT,NONTENDER. 

GRBS:129mg/dl.@9AM 


A:ALTERED SENSORIUM( RESOLVED) 2°TO HYPOGLYCEMIA(RESOLVED) WITH LEFT UPPER LOBE ABSCESS WITH 

WITH  ANEMIA(NORMOCHROMIC NORMOCYTIC). 

WITH HYPOKALEMIA 2°TO GI LOSSES, WITH DM2 SINCE 1 MONTH 

?WEGENERS GRANULOMATOSIS 

?CHURG STRAUSS 

HYPOGLYCEMIA RESOLVED

P:

IVF-NS@75ml/hr.

INJ:PIPTAZ 4.5 g /iv/TID.

INJ:CLINDAMYCIN 600mg/iv/TID.

Tab.SPOROLAC PO/TID

SYP:POTCHLOR 15ml/PO/TID

SYP.ARISTOZYME 15ml/PO/TID.

PLANNING FOR SPLIT SKIN SMEAR.


☆SPLIT SKIN BIOPSY WAS NOT DONE ON 28/04/2023 BECAUSE THE  PATIENT BECAME HYPOTENSIVE DURING THAT TIME.

☆WE REFERRED THE PATEINT TO ENT THEY DID DNE

 https://youtu.be/OzhY-tvTfOg

▪︎This is the YouTube video showing is DNE☝





29/04/2023



S:
No fever spikes 
Complaints of loose stools decreased 


O:
Patient is conscious,coherent,cooperative
Temp:Afebrile 
BP:100/60mmhg.
PR:78bpm.
RR:20cpm.
CVS:S1,S2HEARD ,NO MURMURS. 
RS:BAE+,NVBS.
P/A:SOFT,NONTENDER. 
GRBS:96mg/dl.@9AM 

A:ALTERED SENSORIUM( RESOLVED) 2°TO HYPOGLYCEMIA WITH LEFT UPPER LOBE ABSCESS WITH CUTANEOUS ABSCESS WITH ?CHURG STRAUSS ? WEGENERS GRANULOMATOSIS,WITH  ANEMIA(NORMOCHROMIC NORMOCYTIC). 
WITH HYPOKALEMIA 2°TO GI LOSSES, WITH DM2 SINCE 1 MONTH 


P:
IVF-NS@75ml/hr.
INJ:PIPTAZ 4.5 g /iv/TID.
INJ:CLINDAMYCIN 600mg/iv/TID.
Tab.SPOROLAC PO/TID
SYP:POTCHLOR 15ml/PO/TID
SYP.ARISTOZYME15ml/PO/TID

SPLIT SKIN SMEAR AND SKIN BIOPSY DONE




 


30/04/23




S:
No fever spikes 
Stools passed (1episode of loose stools)


O:
Patient is conscious,coherent,cooperative
Temp:Afebrile on touch
BP:120/60mmhg.
PR:76bpm.
RR:19cpm.
CVS:S1,S2HEARD ,NO MURMURS. 
RS:BAE+,NVBS.
P/A:SOFT,NONTENDER. 
GRBS:200mg/dl.@9AM . 

A:ALTERED SENSORIUM( RESOLVED) 2°TO HYPOGLYCEMIA WITH LEFT LUNG UPPER LOBE ABSCESS WITH CUTANEOUS ABSCESS  (MRSA) ?WEGENERS GRANULOMATOSIS 
?CHURG STRAUSS 
WITH ANEMIA(NORMOCHROMIC NORMOCYTIC). 
WITH HYPOKALEMIA 2°TO GI LOSSES(RESOLVING), WITH DM2 SINCE 1 MONTH.



P:

INJ:PIPTAZ 4.5 g /iv/TID.(DAY 5)
INJ:CLINDAMYCIN 600mg/iv/TID.(DAY 5)
Tab.SPOROLAC PO/TID
SYP:POTKLOR 10ml/PO/TID in 1 glass of water
SYP.ARISTOZYME 15ml/PO/OD
FUCID CREAM L/A BD×1WEEK
CEBHYDRA LOTION L/A BD×2WEEKS
THROMBOPHOBE  L/A OINTMENT.
          


                        01/04/2023


S:
No fever spikes 
Stools passed (1episode of loose stools passes)


O:
Patient is conscious,coherent,cooperative
Temp:Afebrile on touch
BP:120/80mmhg.
PR:70bpm.
RR:19cpm.
CVS:S1,S2HEARD ,NO MURMURS. 
RS:BAE+,NVBS.
P/A:SOFT,NONTENDER. 
GRBS:126mg/dl.@9AM . 

A:

ALTERED SENSORIUM( RESOLVED) 2°TO HYPOGLYCEMIA WITH LEFT LUNG UPPER LOBE ABSCESS WITH CUTANEOUS ABSCESS  (MRSA) ?WEGENERS GRANULOMATOSIS 
?CHURG STRAUSS 
WITH ANEMIA(NORMOCHROMIC NORMOCYTIC). 
WITH HYPOKALEMIA 2°TO GI LOSSES(RESOLVED), WITH DM2 SINCE 1 MONTH.



P:

INJ:PIPTAZ 4.5 g /iv/TID.(DAY 5)
INJ:CLINDAMYCIN 600mg/iv/TID.(DAY 5)
Tab.SPOROLAC PO/TID
SYP:POTKLOR 10ml/PO/TID in 1 glass of water
SYP.ARISTOZYME 15ml/PO/OD
FUCID CREAM L/A BD×1WEEK
CEBHYDRA LOTION L/A BD×2WEEKS
THROMBOPHOBE  L/A OINTMENT.


                 DISCHARGE SUMMARY:

Final diagnosis :

ALTERED SENSORIUM( RESOLVED) 2°TO HYPOGLYCEMIA WITH LEFT LUNG UPPER LOBE ABSCESS WITH CUTANEOUS ABSCESS  (MRSA) ?WEGENERS GRANULOMATOSIS 

?CHURG STRAUSS 

WITH ANEMIA(NORMOCHROMIC NORMOCYTIC). 

WITH HYPOKALEMIA 2°TO GI LOSSES(RESOLVED), WITH DM2 SINCE 1 MONTH.

Bronchial asthma since 30 years



56 year old brought to the casualty  in unresponsive state at 1:30 Am .patient was found drowsy from 1 pm on 25/04/2023 And suddenly developed seizure like activity.

Patient was apparently asymptomatic 6 months back then he developed multiple swellings over the Cheek, Forearm, legs with discharging pus with no pain for which he went to an RMP and he prescribed Antibiotics but it resolved for some days and then reappeared in 10-15 days. He also developed swelling on the nose 6 months back and the RMP removed the pus.,After somedays it healed but the nose became a saddle nose.

1 month back He developed Edema of legs which was insidious in onset and gradually progressive in nature which is progressed from ankle to knees which is of pitting type. for which they went to hospital and was diagnosed with DM2 and .on glimiperide 1mg and metfromin 500mg.

Past history :

Bronchial asthma  since 30 years on deriphylline and Decadron SOS

Course in hospital :

Patient was investigated further and found to have left upper lobe lung abscess other than his cutaneous abscesses and also investigated for his saddle nose with no mucosal abnormality on nasal endoscopy. Biopsies from skin were sent and report is awaited. He's being discharged and asked to follow with the report of the biopsy.









Patient grbs at the time of discharge -252mg/dl
Patient has been asked to buy glucometer
Patient explained method of using glucometer with precaution to avoid repeatedly using same needle
Patient has been asked to update grbs value daily in the group
After 1 week to come to the opd for test and to prescribe medication for DM

Patient explained what to do when grbs decreases to less than 100
Asked to only take the dose as said by the doctor


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